解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3006
更新日期:2013-01-01 00:00:00
abstract::In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigene synapsin family (SYN1/2/3) of synaptic vesicle phosphop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2515
更新日期:2013-01-01 00:00:00
abstract::Shifting between goal-directed and habitual actions allows for efficient and flexible decision making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm, in which mice shift between goal-directed and habitual actions. We identify a role for orbitofrontal cortex (OFC) in actions following...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3264
更新日期:2013-01-01 00:00:00
abstract::Single spins in the solid state offer a unique opportunity to store and manipulate quantum information, and to perform quantum-enhanced sensing of local fields and charges. Optical control of these systems using techniques developed in atomic physics has yet to exploit all the advantages of the solid state. Here we de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2519
更新日期:2013-01-01 00:00:00
abstract::Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2593
更新日期:2013-01-01 00:00:00
abstract::The downstream consequences of inflammation in the adult mammalian heart are formation of a non-functional scar, pathological remodelling and heart failure. In zebrafish, hydrogen peroxide released from a wound is the initial instructive chemotactic cue for the infiltration of inflammatory cells, however, the identity...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3081
更新日期:2013-01-01 00:00:00
abstract::Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2540
更新日期:2013-01-01 00:00:00
abstract::Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2580
更新日期:2013-01-01 00:00:00
abstract::A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2543
更新日期:2013-01-01 00:00:00
abstract::Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2595
更新日期:2013-01-01 00:00:00
abstract::During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasm...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3244
更新日期:2013-01-01 00:00:00
abstract::Although optical technology provides the best solution for the transmission of information, all-optical devices must satisfy several qualitative criteria to be used as logic elements. In particular, cascadability is difficult to obtain in optical systems, and it is assured only if the output of one stage is in the cor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2734
更新日期:2013-01-01 00:00:00
abstract::Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2829
更新日期:2013-01-01 00:00:00
abstract::N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2822
更新日期:2013-01-01 00:00:00
abstract::Graphene is a single-atomic-layer material with excellent mechanical properties and has the potential to enhance the strength of composites. Its two-dimensional geometry, high intrinsic strength and modulus can effectively constrain dislocation motion, resulting in the significant strengthening of metals. Here we demo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3114
更新日期:2013-01-01 00:00:00
abstract::Crustal fluids exist near fault zones, but their relation to the processes that generate earthquakes, including slow-slip events, is unclear. Fault-zone fluids are characterized by low electrical resistivity. Here we investigate the time-dependent crustal resistivity in the rupture area of the 1999 Mw 7.6 Izmit earthq...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3116
更新日期:2013-01-01 00:00:00
abstract::Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3297
更新日期:2013-01-01 00:00:00
abstract::Astrocytes migrate from the optic nerve into the inner retina, forming a template upon which retinal vessels develop. In the Nuc1 rat, mutation in the gene encoding βA3/A1-crystallin disrupts both Notch signalling in astrocytes and formation of the astrocyte template. Here we show that loss of βA3/A1-crystallin in ast...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2624
更新日期:2013-01-01 00:00:00
abstract::The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we determine the emb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2643
更新日期:2013-01-01 00:00:00
abstract::Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3707
更新日期:2013-01-01 00:00:00
abstract::In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3417
更新日期:2013-01-01 00:00:00
abstract::Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3246
更新日期:2013-01-01 00:00:00
abstract::The mitochondrial respiratory chain is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Little is known about factors that contribute to supercomplex organization. Here we identify COX7RP as a factor that promotes supe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3147
更新日期:2013-01-01 00:00:00
abstract::Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3615
更新日期:2013-01-01 00:00:00
abstract::The NASA MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) spacecraft entered orbital phase around Mercury on 18 March 2011. A surprising consistent feature in the data returned is large-scale vortices that form exclusively on the dusk side of the magnetosphere. Here we present global kinetic hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2676
更新日期:2013-01-01 00:00:00
abstract::Understanding climate change-associated tree mortality is central to linking climate change impacts and forest structure and function. However, whether temporal increases in tree mortality are attributed to climate change or stand developmental processes remains uncertain. Furthermore, interpreting the climate change-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2681
更新日期:2013-01-01 00:00:00
abstract::The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is responsible for the maturation of proinflammatory cytokines IL-1β and IL-18. The precise molecular mechanism for negative regulation of NLRP3 inflammasome activation needs to be further defined. Here we id...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3075
更新日期:2013-01-01 00:00:00
abstract::Deep subsurface formations (for example, high-temperature oil reservoirs) are candidate sites for carbon capture and storage technology. However, very little is known about how the subsurface microbial community would respond to an increase in CO2 pressure resulting from carbon capture and storage. Here we construct m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2998
更新日期:2013-01-01 00:00:00
abstract::Groups of people or even robots often face problems they need to solve together. Examples include collectively searching for resources, choosing when and where to invest time and effort, and many more. Although a hierarchical ordering of the relevance of the group members' inputs during collective decision making is a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3484
更新日期:2013-01-01 00:00:00
abstract::Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3676
更新日期:2013-01-01 00:00:00
abstract::Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3008
更新日期:2013-01-01 00:00:00
abstract::New microbial genomes are constantly being sequenced, and it is crucial to accurately determine their taxonomic identities and evolutionary relationships. Here we report PhyloPhlAn, a new method to assign microbial phylogeny and putative taxonomy using >400 proteins optimized from among 3,737 genomes. This method meas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3304
更新日期:2013-01-01 00:00:00
abstract::NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3510
更新日期:2013-01-01 00:00:00
abstract::Calcareous microplankton shells form the dominant components of ancient and modern pelagic sea-floor carbonates and are widely used in palaeoenvironmental reconstructions. The efficacy of these applications, however, is dependent upon minimal geochemical alteration during diagenesis, but these modifying processes are ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3052
更新日期:2013-01-01 00:00:00
abstract::The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3727
更新日期:2013-01-01 00:00:00
abstract::Sodium-ion batteries are an alternative to lithium-ion batteries for large-scale applications. However, low capacity and poor rate capability of existing anodes are the main bottlenecks to future developments. Here we report a uniform coating of antimony sulphide (stibnite) on graphene, fabricated by a solution-based ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3922
更新日期:2013-01-01 00:00:00
abstract::Breaking time-reversal symmetry enables the realization of non-reciprocal devices, such as isolators and circulators, of fundamental importance in microwave and photonic communication systems. This effect is almost exclusively achieved today through magneto-optical phenomena, which are incompatible with integrated tec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3407
更新日期:2013-01-01 00:00:00
abstract::A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3576
更新日期:2013-01-01 00:00:00
abstract::Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3319
更新日期:2013-01-01 00:00:00
abstract::The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2819
更新日期:2013-01-01 00:00:00